Opportunities and challenges in developing tissue-agnostic anti-cancer drugs. 2000 Dying with cancer: patients’ function, symptoms, and care preferences as death approaches. Mccarthy EP, Phillips RS, Zhong Z, Drews RE, Lynn J. Patient and caregiver preferences for first-line treatments of metastatic non-small cell lung cancer: a discrete choice experiment. Yong C, Cambron-Mellott MJ, Seal B, Will O, Maculaitis MC, Clapp K, et al. Mindfulness, death anxiety, and grief in a patient with metastatic cancer. Understanding existential anxiety and the soothing nature of nostalgia in life with incurable esophageal cancer: a phenomenological hermeneutical investigation of patient narratives. Missel M, Bergenholtz H, Beck M, Donsel PO, Simonÿ C. The uncertain presence: experiences of living with metastatic breast cancer. Uncertainty, lack of control and emotional functioning in women with metastatic breast cancer: a review and secondary analysis of the literature using the critical appraisal technique. In the era of tumor agnostic therapies, the elicitation of patient preferences across the spectrum of anatomical origins has the potential to enhance shared decision making in the setting of metastatic disease.

An opportunity exists to potentially address these needs through matching patient needs and preferences with the characteristics of novel therapeutics. The explication of the interplay between the physical and emotional symptoms experienced by those with advanced and metastatic cancer using a multi-tumor approach provides the potential to make generalizations about the needs of this population.

Three major themes emerged that formed the basis for the tumor-agnostic conceptual model: symptoms, loss of autonomy, and adaptation/coping. All papers originated from the USA, Europe, Australia, or Japan. Of the 173 hits generated from the searches, 25 peer-reviewed papers were selected for the review with dates that ranged from 2007 to 2022. No limits were imposed for dates nor location of studies. DesignĪutomated queries on three internet search engines were performed to identify qualitative interview studies that focused on people with metastatic cancer. The present study undertakes a scoping review of research into the experiences of people with advanced or metastatic cancer across various solid tumor types with the goal of developing a tumor-agnostic conceptual model. Through the introduction of tumor agnostic therapies, people with metastatic cancer and their treating physicians are facing new treatment choices that have differing side effect and efficacy profiles from conventional chemotherapy.

Devonagent pro google scholar